Education and Its Discontents: Teaching, the Humanities, and the Importance of a Liberal Education in the Age of Mass Information, by Mark Moss, is an exploration of how the traditional educational environment, particularly in the post-secondary world, is changing as a consequence of the influx of new technology. Students now have access to myriad of technologies that instead of supplementing the educational process, have actually taken it over. Faculty who do not adapt face enormous obstacles, and those who (...) do adapt run the risk of eroding the integrity of what they have been trained to teach. Moss discusses that it is now not only how we learn, but what we continue to teach, and how that enormously important legacy is protected. (shrink)

“His hypothesis is that if you take dope you’re going to end up taking smack, but he’d actually got an incorrect application of Bayes’ theorem... the gateway theory, all obviously complete bollocks, based on a professor’s ineptitude in statistics.”.

Once upon a time, medicine dismissed narrative as unimportant and uninteresting. Then, in the late 1980s, physicians and scholars became interested in how the study of narrative could enhance our understanding of illness and health care, and the field that came to be known as “narrative medicine” developed. Some of this scholarly activity focused on the idea of narrative ethics.After a flurry of activity around the turn of the twenty‐first century, narrative ethics seemed to stall. The general interest in narrative (...) in medicine continued but with few new ideas on how one might use narrative toward ethical ends. In the last few years, however, forward momentum has returned. The timing seems appropriate, therefore, for a “state of the field” report of sorts. (shrink)

The concept of a reason is now central to many areas of contemporary philosophy. Key theses in ethics, epistemology, political philosophy, philosophy of action, and the philosophy of the emotions, among others, have come to be framed in terms of reasons. And yet, despite their centrality, theorists seem to take inconsistent things for granted about how reasons work, what kinds of things can be reasons, what reasons favor, and more. Somehow reasons have come to be both indispensable and impenetrable. -/- (...) The Fundamentals of Reasons offers a comprehensive introduction to the philosophy of reasons. Focusing on the twin roles of reasons in explanation and deliberation, the book not only emphasizes what has made reasons central across philosophy but it also explores why philosophers have such incompatible pictures about what reasons are and how they work. Working from the inside out, Howard and Schroeder identify contentious assumptions about not only the internal structure of reasons but also their relationship to other important concepts, and then show how these contentious assumptions shape the many downstream applications of reasons in ethics, epistemology, political philosophy, and beyond. -/- This mildly opinionated exploration of key questions about the significance and nature of reasons helps the reader to navigate this important part of the philosophical landscape and to get clearer about why reasons seem important and what their import, ultimately, is. (shrink)

The Institutional Animal Care and Use Committee is entrusted with assessing the ethics of proposed projects prior to approval of animal research. The role of the IACUC is detailed in legislation and binding rules, which are in turn inspired by the Three Rs: the principles of Replacement, Reduction, and Refinement. However, these principles are poorly defined. Although this provides the IACUC leeway in assessing a proposed project, it also affords little guidance. Our goal is to provide procedural and philosophical clarity (...) to the IACUC without mandating a particular outcome. To do this, we analyze the underlying logic of the Three Rs and conclude that the Three Rs accord animals moral standing, though not necessarily “rights” in the philosophical sense. We suggest that the Rs are hierarchical, such that Replacement, which can totally eliminate harm, should be considered prior to Reduction, which decreases the number of animals harmed, with Refinement being considered last. We also identify the need for a hitherto implicit fourth R: Reject, which allows the IACUC to refuse permission for a project which does not promise sufficient benefit to offset the pain and distress likely to be caused by the proposed research. (shrink)

What would Karl Popper have made of today’s management and organisation theories? He would surely have approved of the openness of debate in some quarters, but the ease with which many managers accept the generalisations of some academics, gurus and consultants might well have troubled him. Popper himself argued that processes of induction alone were unlikely to lead to developments in knowledge and considered processes of justification to be more important. He claimed that it was not through verifying theories from (...) experiment that knowledge actually developed but through the invention of bold and innovative theories that experimenters then tried to falsify. If new theories did not agree with the results of experiment, then they were considered false. If they passed testing then they were considered unfalsified and worthy of further testing rather than true. Objective knowledge was to be obtained through ensuring critical debate and learning, rather than adhering to some objective scientific method. In this paper, Popper’s notion of falsificationism is explored through stressing the importance of the predictive content and testability of theories. A number of theories from the fields of management and organisation theory are examined and it is argued that many of them suffer from one of three defects: from over-reliance upon untestable elements with psychological origins; from being phrased in language so vague that they gloss over phenomena; or from making predictions that are so cautious and allencompassing as to be practically useless. As a result, they are likely to be unfalsifiable in Popper’s terms and their epistemological status is called into question. While acknowledging that the unpredictability of social systems poses problems for an approach stressing predictability, I conclude by arguing that organisation theory and management knowledge might well benefit from the openness and critical nature of Popper’s approach. (shrink)

ces, learning facts and gaining conceptual knowlge, recognizing objects and people, and acquiring ills and habits. Scientific thinking about memory was minated for many years by the assumption that mory is a unitary or monolithic entityRi2;a single ulty of the mind and brain. However, the assumpri of a unitary memory has been challenged by conging evidence from psychology and neuroscience inting toward multiple memory systems that can be sociated from one another. This chapter provides a torical introduction to the issue (...) and summarizes.. (shrink)

Technology corporations and the emerging digital health market are exerting increasing influence over the public healthcare agendas forming around the application of mobile medical devices. By promising quick and cost-effective technological solutions to complex healthcare problems, they are attracting the interest of funders, researchers, and policymakers. They are also shaping the public facing discourse, advancing an overwhelmingly positive narrative predicting the benefits of wearable medical devices to include personalised medicine, improved efficiency and quality of care, the empowering of under-resourced communities, (...) and delivery of health services previously unavailable to the citizens of developing countries. Typically techno-optimist in their description, the key barriers to this impending inflection point in healthcare are identified as technical issues such as short battery life and a lack of data protection. However, this tech innovation narrative is consistent with problematic ethical, social, and political assumptions that have practical and normative effects, and risk, one, undermining the real clinical potential of wearable devices and, two, designing social inequality and injustice into our mobile health interventions in global healthcare. I argue that the foundational assumptions dealing with the just distribution of healthcare ‘goods’, the individual as part of society, and the political framing of future healthcare policy devalue equity and despite what they promise cannot meet the distinctive needs of individuals and groups that do not conform to a standardised concept of care-receiver. (shrink)

Background: Current practice frequently fails to provide care consistent with the preferences of decisionally-incapacitated patients. It also imposes significant emotional burden on their surrogates. Algorithmic-based patient preference predictors (PPPs) have been proposed as a possible way to address these two concerns. While previous research found that patients strongly support the use of PPPs, the views of surrogates are unknown. The present study thus assessed the views of experienced surrogates regarding the possible use of PPPs as a means to help make (...) treatment decisions for decisionally-incapacitated patients. -/- Methods: This qualitative study used semi-structured interviews to determine the views of experienced surrogates [n=26] who were identified from two academic medical centers and two community hospitals. The primary outcomes were respondents’ overall level of support for the idea of using PPPs and the themes related to their views on how a PPP should be used, if at all, in practice. -/- Results: Overall, 21 participants supported the idea of using PPPs. The remaining five indicated that they would not use a PPP because they made decisions based on the patient’s best interests, not based on substituted judgment. Major themes which emerged were that surrogates, not the patient’s preferences, should determine how treatment decisions are made, and concern that PPPs might be used to deny expensive care or be biased against minority groups. -/- Conclusions: Surrogates, like patients, strongly support the idea of using PPPs to help make treatment decisions for decisionally-incapacitated patients. These findings provide support for developing a PPP and assessing it in practice. At the same time, patients and surrogates disagree over whose preferences should determine how treatment decisions are made, including whether to use a PPP. These findings reveal a fundamental disagreement regarding the guiding principles for surrogate decision-making. Future research is needed to assess this disagreement and consider ways to address it. (shrink)

It is likely that sex robots will exist in the near future, making the effect they might have on human relationships a pressing concern. In this future world, we can imagine sex robots shaping our personal and social relationships through their unique access to, and potential for influencing, our most intimate of behaviours. We investigate whether they might be employed to influence social behaviours in a positive way. The paper begins with an account of the state of the art, acknowledges (...) powerful feminist criticisms that have been made of sex robots, and evaluates suggestions that it might be possible to design sex robots which do not raise these concerns and which might even work to influence social behaviours in a positive way. It then outlines a number of ways that sex robots might be used to educate, “nudge”, and influence people in positive ways. It defends the idea that it would be ethical to use sex robots to promote socially positive behaviours — behaviours that benefit others and improve social cohesion, such as fostering respect and empathy for persons — but not to promote commercial products for parochial interests. We argue that the former project could advance individual and social welfare, while preserving personal autonomy — a minimum requirement of which is the ability to make informed decisions — whereas the latter depends on a lack of transparency and democratic control for its success, targets the vulnerability of the user to achieve its ends, and reinforces the problematic symbolism of negatively gendered sexuality. If sex robot design and application meet public requirements of transparency — enabling informed consent and reflective decision making — and democratic oversight — promoting accountability and the sharing of power with the public — it is conceivable that sex robots might assist, rather than harm society. (shrink)

We prove a theorem (1.7) about partial orders which can be viewed as a version of the Barwise compactness theorem which does not mention logic. The Barwise compactness theorem is easily equivalent to 1.7 + "Every Henkin set has a model". We then make the observation that 1.7 gives us the definability of forcing for quantifier-free sentences in the forcing language and use this to give a direct proof of the truth and definability lemmas of forcing.

Animal research in laboratories is currently informed by the three R’s (Replacement, Reduction, and Refinement), a common-sense theory of animal research ethics. In addition a fourth R (Refusal) is needed to address research plans that are so badly conceived that their chances of gaining any knowledge worth the animal suffering they cause are nil. Unfortunately, these four R’s do not always yield workable solutions to the moral problems faced regularly by wildlife researchers. It is possible to develop analogs in the (...) sphere of environmental research to these four R’s, creating a common-sense theory of environmental research ethics that will provide significant guidance to researchers and win acceptance from almost all stakeholders. This theory can be articulated in terms of twenty basic principles. (shrink)

The World Health Organisation (WHO) is leading a global effort to deliver improved diagnostic testing to people living in low‐resource settings. A reliance on the healthcare technologies marketplace and industry, shapes many aspects of the WHO project, and in this situation normative guidance comes by way of the ASSURED criteria — Affordable, Sensitive, Specific, User‐friendly, Rapid and robust, Equipment‐free, and Delivered. While generally improving access to diagnostics, I argue that the ASSURED approach to distributive justice — efficiency — and assessment (...) of worth — productivity — may constrain efforts to deliver timely and accurate diagnosis in the developing world equitably by holding back new and innovative diagnostics and indirectly encouraging program and device design that may unfairly discriminate against certain groups. Even as we try to overcome the problem of global healthcare injustice, we may be entrenching disadvantage. I present my critique of ASSURED by 1) referencing Boltanski and Thévenot's theory of orders of worth to highlight the industrial and market foundations of the ASSURED guidelines; 2) comparing ASSURED with other normative guides that elevate the importance of civic responsibility in evaluations of distributive justice; 3) presenting a case study of the failed promise of microfluidic diagnostic devices. I conclude that a new approach to normative guidance is required to assess the value of developing world diagnostics, preferably, one that does not force global public goods into the marketplace. (shrink)

Hastings Center Report, Volume 52, Issue 2, Page 41-48, March‐April 2022.

Artificial intelligence (AI) systems have demonstrated impressive performance across a variety of clinical tasks. However, notoriously, sometimes these systems are 'black boxes'. The initial response in the literature was a demand for 'explainable AI'. However, recently, several authors have suggested that making AI more explainable or 'interpretable' is likely to be at the cost of the accuracy of these systems and that prioritising interpretability in medical AI may constitute a 'lethal prejudice'. In this paper, we defend the value of interpretability (...) in the context of the use of AI in medicine. Clinicians may prefer interpretable systems over more accurate black boxes, which in turn is sufficient to give designers of AI reason to prefer more interpretable systems in order to ensure that AI is adopted and its benefits realised. Moreover, clinicians may be justified in this preference. Achieving the downstream benefits from AI is critically dependent on how the outputs of these systems are interpreted by physicians and patients. A preference for the use of highly accurate black box AI systems, over less accurate but more interpretable systems , may itself constitute a form of lethal prejudice that may diminish the benefits of AI to - and perhaps even harm - patients. (shrink)

Artificial intelligence (AI) systems have demonstrated impressive performance across a variety of clinical tasks. However, notoriously, sometimes these systems are “black boxes.” The initial response in the literature was a demand for “explainable AI.” However, recently, several authors have suggested that making AI more explainable or “interpretable” is likely to be at the cost of the accuracy of these systems and that prioritizing interpretability in medical AI may constitute a “lethal prejudice.” In this paper, we defend the value of interpretability (...) in the context of the use of AI in medicine. Clinicians may prefer interpretable systems over more accurate black boxes, which in turn is sufficient to give designers of AI reason to prefer more interpretable systems in order to ensure that AI is adopted and its benefits realized. Moreover, clinicians may be justified in this preference. Achieving the downstream benefits from AI is critically dependent on how the outputs of these systems are interpreted by physicians and patients. A preference for the use of highly accurate black box AI systems, over less accurate but more interpretable systems, may itself constitute a form of lethal prejudice that may diminish the benefits of AI to—and perhaps even harm—patients. (shrink)

Angelaki, Volume 16, Issue 1, Page 1-3, 01Mar2011.

Many authors, including Derek Parfit, T. M. Scanlon, and Mark Schroeder, favor a “reasons-first” ontology of normativity, which treats reasons as normatively fundamental. Others, most famously G. E. Moore, favor a “value-first” ontology, which treats value or goodness as normatively fundamental. Chapter 10 argues that both the reasons-first and value-first ontologies should be rejected because neither can account for all of the normative reasons that, intuitively, there are. It advances an ontology of normativity, originally suggested by Franz Brentano and (...) A. C. Ewing, according to which fittingness is normatively fundamental. The normative relation of fittingness is the relation in which a response stands to an object when the object merits—or is worthy of—that response. The author argues that his “fittingness-first” ontology is no less parsimonious than either the reasons- or the value-first ontology, but it can plausibly accommodate the existence of all the normative reasons there are. It therefore provides a superior ontology of normativity. (shrink)

This paper provides a foundation for the polarity marking technique introduced by David Dowty [3] in connection with monotonicity reasoning in natural language and in linguistic analyses of negative polarity items based on categorial grammar. Dowty's work is an alternative to the better-known algorithmic approach first proposed by Johan van Benthem [11], and elaborated by Víctor Sánchez Valencia [10]. Dowty's system internalized the monotonicity/polarity markings by generating strings using a categorial grammar whose categories already contain the markings that the earlier (...) system would obtain by separate steps working on an already-derived string. Despite the linguistic advantages of the internalized system, no soundness proof has yet been given for it. This paper offers an account. The leading mathematical idea is to interpret categorial types as preorders (in order to talk about monotonicity in the first place), and then to add a primitive operation to the type hierarchy of taking the opposite of a preorder (in order to capture monotone decreasing functions). At the same time, the use of internalized categories also raises issues. Although these will not be addressed in full, the paper points out possible approaches to them. (shrink)

Jaswal & Akhtar provide several quotes ostensibly from people with autism but obtained via the discredited techniques of Facilitated Communication and the Rapid Prompting Method, and they do not acknowledge the use of these techniques. As a result, their argument is substantially less convincing than they assert, and the article lacks transparency.

Childhood adversity is associated with altered or dysregulated stress reactivity; these altered patterns of physiological functioning persist into adulthood. Evidence from both preclinical animal models and human neuroimaging studies indicates that early life experience differentially influences stressor-evoked activity within central visceral neural circuits proximally involved in the control of stress responses, including the subgenual anterior cingulate cortex (sgACC), paraventricular nucleus of the hypothalamus (PVN), bed nucleus of the stria terminalis (BNST) and amygdala. However, the relationship between childhood adversity and the (...) resting-state connectivity of this central visceral network remains unclear. To this end, we examined relationships between childhood threat and childhood socioeconomic deprivation, the resting-state connectivity between our regions of interest (ROIs), and affective symptom severity and diagnoses. We recruited a transdiagnostic sample of young adult males and females (n= 100; mean age = 27.28,SD= 3.99; 59 females) with a full distribution of maltreatment history and symptom severity across multiple affective disorders. Resting-state data were acquired using a 7.2-min functional magnetic resonance imaging (fMRI) sequence; noted ROIs were applied as masks to determine ROI-to-ROI connectivity. Threat was determined by measures of childhood traumatic events and abuse. Socioeconomic deprivation (SED) was determined by a measure of childhood socioeconomic status (parental education level). Covarying for age, race and sex, greater childhood threat was significantly associated with lower BNST-PVN, amygdala-sgACC and PVN-sgACC connectivity. No significant relationships were found between SED and resting-state connectivity. BNST-PVN connectivity was associated with the number of lifetime affective diagnoses. Exposure to threat during early development may entrain altered patterns of resting-state connectivity between these stress-related ROIs in ways that contribute to dysregulated neural and physiological responses to stress and subsequent affective psychopathology. (shrink)

The history of recent research on the Gospel of Mark can be seen as the record of an attempt to discern the aim of the Evangelist and so to discover the perspective which gives coherence to all the features of the Second Gospel.

In Paradigms and Barriers Howard Margolis offers an innovative interpretation of Thomas S. Kuhn's landmark idea of "paradigm shifts," applying insights from cognitive psychology to the history and philosophy of science. Building upon the arguments in his acclaimed Patterns, Thinking, and Cognition, Margolis suggests that the breaking down of particular habits of mind—of critical "barriers"—is key to understanding the processes through which one model or concept is supplanted by another. Margolis focuses on those revolutionary paradigm shifts— such as the (...) switch from a Ptolemaic to a Copernican worldview—where challenges to entrenched habits of mind are marked by incomprehension or indifference to a new paradigm. Margolis argues that the critical problem for a revolutionary shift in thinking lies in the robustness of the habits of mind that reject the new ideas, relative to the habits of mind that accept the new ideas. Margolis applies his theory to famous cases in the history of science, offering detailed explanations for the transition from Ptolemaic to cosmological astronomy, the emergence of probability, the overthrow of phlogiston, and the emergence of the central role of experiment in the seventeenth century. He in turn uses these historical examples to address larger issues, especially the nature of belief formation and contemporary debates about the nature of science and the evolution of scientific ideas. Howard Margolis is a professor in the Harris Graduate School of Public Policy Studies and in the College at the University of Chicago. He is the author of Selfishness, Altruism, and Rationality and Patterns, Thinking, and Cognition, both published by the University of Chicago Press. (shrink)

From a subjective point of view, we take the existence of integrated entities, i.e., ourselves as the most unproblematic given, and blithely project such integrity onto untold many “entities” far and wide. However, from a naturalistic perspective, accounting for anything more integral than the attachments and attractions that are explicable in terms of the four fundamental forces of physics has been anything but straightforward. If we take it that the universe begins as an integral unity and explodes into progressive stages (...) of internal detachment, then we can also fathom the idea that eddies of relative detachment becoming increasingly integral. Helmuth Plessner made a powerful case for the onset of “positionality” constituting one of the major transitions in nature. Surely, the emergence of “entities” that position themselves in relation to their surround marks a decisive transition in relative levels of detachment and some would say “autonomy.” It would follow, with no less force, that where and when entities can be seen to be normatively integrated, and indeed to be the agents of their own normativity, that another threshold of detachment has been crossed. The paper introduces and explores the idea that normativity, embedded in a wide-ranging theory of natural detachment, can be considered an emergent force of nature that is requisite to accounting for levels of integration beyond that which is explicable in terms of the four fundamental forces of physics. Following this line of enquiry, we argue that the first expression of a fully, normatively-integrated life-form is neither a spoken language user nor for that matter an individual but rather the neoteny-based, Homo erectus Group. In so doing we claim to have made an inroad into embedding the force of normativity into a wide-ranging naturalist framework, to have provided philosophical anthropology with a new point of departure, and at least playfully, to have given some naturalistic grist to Hegel’s proclamation that spirit is the truth of nature. (shrink)

This book celebrates the work of Patricia Werhane, an iconic figure in business ethics. This festschrift is a collection of articles that build on Werhane’s contributions to business ethics in such areas as Employee Rights, the Legacy of Adam Smith, Moral Imagination, Women in Business, the development of the field of business ethics, and her contributions to such fields as Health Care, Education, Teaching, and Philosophy. All papers are new contributions to the management literature written by well-known business ethicists, such (...) as Norman Bowie, Richard De George, Ronald Duska, Edwin Hartman, Michael Hoffman, Mollie Painter-Morland, Mark Schwartz, Andrew Wicks, and others. The volume is comprised of articles that reflect on Werhane’s work as well as build on it as a way to advance further research. At the end of the festschrift, Pat Werhane provides responses to each chapter. The first chapter of the book also includes the overview of Patricia Werhane’s work and her academic career. The book is written to appeal to management scholars and graduate students interested in the areas of Business Ethics, Modern Capitalism, and Human Rights. Patricia Werhane is one of the most distinguished figures in the field of business ethics. She was a founder of the field, she is one of its leading scholars, and she has had a profound impact on the world of business practice. Among her many accomplishments, Pat is known for her original work on moral imagination, she is an acclaimed authority on employee rights in the workplace, and she is one of the leading scholars on Adam Smith. Having been active in Academia for over 50 years, Werhane is a prolific author of over a hundred articles and book chapters, and the author or editor of twenty-seven books, including Adam Smith and his Legacy for Modern Capitalism, Moral Imagination and Management Decision-Making, and co-authored books Organization Ethics in Health Care, Alleviating Poverty Through Profitable Partnerships, Obstacles to Ethical Decision-Making, Corporate Responsibility: The American Experience, and Research Approaches to Business Ethics and Corporate Responsibility. (shrink)

Preparative and analytical methods developed by separation scientists have played an important role in the history of molecular biology. One such early method is gel electrophoresis, a technique that uses various types of gel as its supporting medium to separate charged molecules based on size and other properties. Historians of science, however, have only recently begun to pay closer attention to this material epistemological dimension of biomolecular science. This paper substantiates the historiographical thread that explores the relationship between modern laboratory (...) practice and the production of scientific knowledge. It traces the historical development of gel electrophoresis from the mid-1940s to the mid-1960s, with careful attention to the interplay between technical developments and disciplinary shifts, especially the rise of molecular biology in this time-frame. Claiming that the early 1950s marked a decisive shift in the evolution of electrophoretic methods from moving boundary to zone electrophoresis, I reconstruct various trajectories in which scientists such as Oliver Smithies sought out the most desirable solid supporting medium for electrophoretic instrumentation. Biomolecular knowledge, I argue, emerged in part from this process of seeking the most appropriate supporting medium that allowed for discrete molecular separation and visualization. The early 1950s, therefore, marked not only an important turning point in the history of separation science, but also a transformative moment in the history of the life sciences as the growth of molecular biology depended in part on the epistemological access to the molecular realm available through these evolving technologies. (shrink)

What is faith? Lara Buchak has done as much as anyone recently to answer our question in a sensible and instructive fashion. As it turns out, her writings reveal two theories of faith, an early one and a later one (or, if you like, two versions of the same theory). In what follows, we aim to do three things. First, we will state and assess Buchak’s early theory, highlighting both its good-making and bad-making features. Second, we will do the same (...) for her later theory, noting improvements on the early one. Third, we will mark various choice points in theorizing about faith, and we will argue for specific choices at those points, culminating in what we regard as a better, alternative theory of faith. Our critical aims, therefore, are ultimately constructive. By theorizing about faith with Lara Buchak, we aim to contribute to our common understanding of what faith is. (shrink)

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

According to many accounts of faith—where faith is thought of as something psychological, e.g., an attitude, state, or trait—one cannot have faith without belief of the relevant propositions. According to other accounts of faith, one can have faith without belief of the relevant propositions. Call the first sort of account doxasticism since it insists that faith requires belief; call the second nondoxasticism since it allows faith without belief. The New Testament may seem to favor doxasticism over nondoxasticism. For it may (...) seem that, according to the NT authors, one can have faith in God, as providential, or faith that Jesus is the Messiah, or be a person of Christian faith, and the like only if one believes the relevant propositions. In this essay, I propose to assess this tension, as it pertains to the Gospel of Mark. The upshot of my assessment is that, while it may well appear that, according to Mark, one can have faith only if one believes the relevant propositions, appearances are deceiving. Mark said no such thing. Rather, what Mark said—by way of story—about faith fits nondoxasticism at least as well as doxasticism, arguably better. More importantly, the account of faith that emerges from Mark is that faith consists in resilience in the face of challenges to living in light of the overall positive stance to the object of faith, where that stance consists in certain conative, cognitive, and behavioral-dispositional elements. (shrink)

In some circles, faith is said to be one of three theological virtues, along with hope and agape. But not everyone thinks faith is a virtue, theological or otherwise. Indeed, depending on how we understand it, faith may well conflict with the virtues. In this chapter we will focus on the virtue of humility. Does faith conflict with humility, or are they in concord? In what follows, we will do five things. First, we will sketch a theory of the virtue (...) of humility. Second, we will summarize a common view of faith, arguably held by Thomas Aquinas among others, and we will argue that Thomistic faith is not an intellectual virtue and that it conflicts with humility in the domain of inquiry. Third, we will plump for an older view of faith, one that predates Aquinas by at least 1500 years, Markan faith. Fourth, we will argue that Markan faith is an intellectual virtue and it is in concord with humility in the domain of inquiry. Fifth, we will argue that Markan faith, unlike Thomistic faith, is a personal virtue and that it is in concord with humility in the domain of personal relationships, both human-human and human-divine. (shrink)

Whilst acknowledging that there are several major differences in the approach which Kant and Marx take to political philosophy this article argues that there are also several common themes. These common themes of commitment to critique, freedom, equality, human betterment and cosmopolitanism are first highlighted. Subsequently the most marked contrasts in their approaches are examined and evaluated. Although Kant demonstrates greater political wisdom and a greater respect for law, Marx shows greater insight into social and political forces. Taken together Kant (...) and Marx present an as yet unrealized, powerful programme for political and social improvement. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

It is here that the precise point of Forster’s manner appears.... The plot suggests eternal division, the manner reconciliation; the plot speaks of clear certainties, the manner resolutely insists that nothing can be quite so simple. “Wash ye, make yourselves clean,” says the plot, and the manner murmurs, “If you can find the soap.”If a great work of literature is one that admits of many interpretations, then E. M. Forster’s Howards End has—at the very least—a great epigraph. “Only connect...”—only connect (...) what, exactly? Various readings have been suggested, most of them plausible: Forster is expressing his wish for “the emergence of a just, harmonious, and whole society” that would overcome the social and... (shrink)